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Streptomycin 3"-adenylyltransferase

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streptomycin 3"-adenylyltransferase
Identifiers
EC no.2.7.7.47
CAS no.52660-23-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins

In enzymology, a streptomycin 3"-adenylyltransferase (EC 2.7.7.47) is an enzyme that catalyzes the chemical reaction:

ATP + streptomycin diphosphate + 3"-adenylylstreptomycin

Thus, the two substrates of this enzyme are ATP and streptomycin, whereas its two products are diphosphate and 3''-adenylylstreptomycin.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:streptomycin 3"-adenylyltransferase. Other names in common use include streptomycin adenylate synthetase, streptomycin adenyltransferase, streptomycin adenylylase, streptomycin adenylyltransferase, streptomycin-spectinomycin adenylyltransferase, AAD (3"), and aminoglycoside 3"-adenylyltransferase.

References

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  • Harwood JH, Smith DH (1969). "Resistance factor-mediated streptomycin resistance". J. Bacteriol. 97 (3): 1262–71. PMC 249843. PMID 4887506.